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This is an illustrative research schedule, not a prescription

Very high doses of vitamin B12 may cause mild symptoms such as: Headache Fatigue or weakness Nausea Vomiting and diarrhea Tingling sensation in hands and feet

It is designated solely as a research chemical

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The clinical escalation protocol from the Phase 2 NEJM trial established a specific titration schedule that increases the dose every four weeks, starting low and building to a target maintenance dose